Toxicological advice on air pollutants [Review of published Environmental Assessment Levels for a number of Substances, based on updated toxicological information]

The main objective of this project is to continue the on-going review and revision of EALs by applying the EA 2012 methodology, updated as appropriate to reflect our consultations (see details below). It will include the production of individual dossiers on the toxicology of specific chemicals from the open and grey scientific literature (the dossiers for selenium and piperazine are provided as examples in Appendix D), which will be the basis for establishing updated EALs, short term and/or long-term depending on the data, for each compound. The proposed EALs will be submitted for agreement by the EA and UKHSA. In addition, the contractors may be required to provide expert advice on request, in the form of a briefing note, for selected toxicological issues such as a synthesis of in vitro and in vivo evidence on genotoxicity and mutagenicity. The work undertaken will be carried out under the direction of the EA's Chief Scientist's Group, who will also liaise with UKHSA. - Estimated timescale would be for the work to be completed by the end of the financial year.